Paul has worked on over one hundred API programmes, covering more than five hundred synthetic process steps. He began his career with Boots Pharmaceuticals in 1977. Later, following his PhD studies, he worked as a development chemist with Courtaulds and then Abbott Laboratories. Since 1995 he has worked in the virtual pharmaceutical arena, first with British Biotech and then with OSI Pharmaceuticals, where he was Senior Director of Chemical Operations, with responsibility for outsourcing, technology transfer, chemical development, scale-up and validation. Paul set up Synth-Isis Ltd in 2004 to provide consultancy services to virtual pharmaceutical and biotechnology companies around the world. The company has an extensive network of service providers and consultants who can offer assistance in virtually any aspect of drug development.