The p300/CBP inhibitor company

We are developing inobrodib, a new drug to benefit people with cancer

  • 50+

    Epigenetic-related targets

    investigated over time by the CellCentric team

  • 1

    Drug prioritised, advanced

    Inobrodib in the clinic, to treat specific cancers

Inobrodib is a first-in-class oral anti-cancer drug that targets twin tumour drivers, p300/CBP. It is a small molecule, formulated as a capsule taken orally, in Phase I/II clinical trials.

p300/CBP are twin (paralogue) acetyl transferases and gene activating proteins that are known to play an important role in the progression of certain cancers.

Inobrodib is a novel drug which inhibits p300/CBP by binding to the twin proteins’ conserved bromodomain. This impacts the growth of specific types of cancer.

CellCentric’s pioneering drug is in clinical trials to evaluate its effectiveness to treat late-stage prostate cancer, haematological malignancies (blood cancers) and tumours with certain molecular drivers (over-expressing AR or MYC; or with a p300 or CBP mutation). These represent major clinical unmet needs, delivering a new therapy for patients that otherwise have few alternatives.

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Looking forward to the Optimum investor conference on Thursday 6 Oct, at the Wellcome Collection, London. pic.twitter.com/845iBeBKK4

CellCentric will present Multiple Myeloma & AML translational and early clinical data at ASH, New Orleans. Inobrodib, pioneering p300/CBP inhibitor. pic.twitter.com/c6EtZU3th0

Delighted to welcome Ruth in her new role as clinical trials manager, based in the Cambridge office. Advancing inobrodib to treat specific cancers. pic.twitter.com/rYv38Q2ocH