CCS1477

First-in-class p300/CBP inhibitor to treat specific cancers

  • 80,000+

    Men with prostate cancer

    could ultimately benefit from CCS1477 annually

  • 20,000+

    Patients with blood cancers

    multiple myeloma, AML, lymphomas

  • 50+

    Epigenetic-related targets

    investigated over time by the CellCentric team

  • 1

    Drug prioritised, advanced

    CCS1477 in the clinic, for multiple indications

The science

CCS1477, a first-in-class small molecule drug to treat prostate and other cancers

There is a large and growing population of prostate cancer patients that are resistant to second generation anti-hormonal drugs (Xtandi, Zytiga, Erleada). CCS1477 addresses this through targeting the key drivers of resistance and late stage disease; the androgen receptor (AR), AR splice variants (AR-SV) and c-Myc.

Other cancer tumours are also susceptible to p300/CBP inhibition, notably specific haematological cancers; multiple myeloma, acute myeloid leukaemia (AML) and certain lymphomas.

Backed by strong pre-clinical data, CCS1477 is now being trialed in patients.

The team

A core team with deep experience of drug discovery and development

The company is supported by a strong network of clinical, scientific and commercial advisors. CellCentric also actively collaborates with a number of world-leading cancer research centres on the effects of CCS1477 and p300/CBP inhibition.

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CellCentric is presenting CCS1477’s translation from mech of action to clinical application at TFDD next week. kisacoresearch.com/events/transcr… @KisacoRes pic.twitter.com/88IK4VIurE

New research paper (Xu et al.): potential of p300 inhibition to treat prostate cancer, incl. re-sensitising tumours to late stage drugs. cancerres.aacrjournals.org/content/early/… pic.twitter.com/SsF6ltZj7z

Our latest corporate deck is on our website: 3 strands of clinical development for our first-in-class p300/CBP inhibitor: cellcentric.com/company/corpor… pic.twitter.com/Zx7AJ3RGVg