CCS1477, a first-in-class small molecule to treat prostate (CRPC) and other cancers

P300/CBP bromodomain inhibitor CCS1477

Our science

CCS1477 inhibits the bromodomains of twin histone acetyl transferase proteins, p300/CBP

There is a large and growing population of prostate cancer patients that are resistant to second generation anti-hormonal drugs. CCS1477 addresses this through lowering the key drivers of this resistance and late stage disease: AR, AR-SV and c-Myc.

Other cancer tumours are also susceptible to p300/CBP inhibition, notably specific haematological, bladder and lung cancers.

Backed by strong pre-clinical data, CCS1477 is now heading to clinical trials.

CellCentric’s scientific foundation is in epigenetics. Having originally spun out of the University of Cambridge, the company has investigated over 50 epigenetic-related targets before focusing on p300/CBP.
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Our team

CellCentric’s team has deep experience of drug discovery and development in oncology

The company is supported by a strong network of clinical, scientific and commercial advisors. CellCentric also actively collaborates with a number of world-leading cancer research centres, on the effects of CCS1477 and p300/CBP inhibition.

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CellCentric heading to Chicago for ASCO. CCS1477 for prostate (CRPC) and other cancers. pic.twitter.com/XAkpb63UYn

CCS1477 first-in-class p300/CBP inhibitor for prostate (CRPC) and other cancers pic.twitter.com/g74RXD1ulI

Thank you ApconiX. CCS1477 successfully steered through pre-clin tox; onward to the clinic. pic.twitter.com/nTPxTu1m7S