CellCentric’s first-in-class small molecule p300/CBP inhibitor, CCS1477, has been selected for the ‘New Drugs on the Horizon’ session at the prestigious annual American Association for Cancer Research (AACR) meeting, this year being held in Atlanta. CellCentric’sResearch Director, Neil Pegg, will be presenting on March 31st 2019. Neil’s presentation will include the first disclosure of the chemical structure of the molecule. The compound is now in Phase I patient clinical testing, initially for prostate cancer, moving on to haematological malignancies.
The twin histone
CCS1477 is a potent, highly selective and orally bioavailable inhibitor of the common bromodomains of p300 and CBP. Neil, in his presentation at AACR, will summarise the pre-clinical evidence supporting CCS1477’s use in the two prioritised target clinical areas, both as a monotherapy and in combination with existing agents. CCS1477 significantly reduces the growth of prostate cancer tumours that are resistant to existing drugs, such as enzalutamide. It also can cause tumour stasis and regression in models of multiple myeloma(MM) and acute myeloid leukaemia (AML). In pre-clinical models, the drug has a prolonged anti-cancer effect that is sustained beyond
Phase I clinical testing of CCS1477 began last year in patients with
Neil Pegg, CellCentric’s Research Director, said: “The targeting of p300/CBP evolved from a deep understanding of epigenetics. Our programme is a combination of strong biology, generation of a well-behaved drug, and clear clinical utility. This is an exciting time as we begin to see promising data generated in patients with significant unmet medical needs.”
Longer term, targeting p300/CBP may have applications in oncology beyond prostate and blood cancers, either through impacting hormone channels or where tumours have a mutation in either p300 or CBP.
CellCentric is a biotechnology company focused on a first-in-class p300/CBP bromodomain inhibitor drug, CCS1477. The company has investigated over 50 potential epigenetic-related drug targets, before focusing on the twin histone
CellCentric is a privately held business, with Morningside Venture Investments as its lead investor. CCS1477’s progress has also benefited from awards from Innovate UK (BioMedical Catalyst) and the Prostate Cancer Foundation. The company maintains active collaborations with multiple research centres in Europe and the US.