A Phase I/IIa study to evaluate the safety and efficacy of CCS1477, a first in clinic inhibitor of p300/CBP, as monotherapy in patients with selected molecular alterations
Aiming to transform outcomes and quality of life for people with cancer
Inobrodib is a small molecule inhibitor, taken orally as a simple capsule. It inhibits p300 and CBP through binding into the conserved bromodomain of the twin proteins. This impacts the expression of key cancer drivers including MYC, IRF4 and the androgen receptor (AR) and its variants.
investigated over time by the CellCentric team
investigated over time by the CellCentric team
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Inobrodib is a first-in-class clinical inhibitor of p300/CBP and is being applied to treat a number of specific cancer types that are currently under addressed:
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PRESS RELEASE: https://www.cellcentric.com/press-release/cellcentic-presents-latest-clinical-data-at-ash-promising-efficacy-and-safety-in-multiple-myeloma/ @DrEmmaSearle at #ASH24 shared latest positive inobrodib clinical data in treating multiple myeloma.
We will be sharing latest clinical data on Monday 5pm PT at #ASH24, San Diego. Inobrodib, our novel oral drug, new MoA, to treat multiple myeloma.
We will be at #ASH24, presenting latest Phase II data: New Drug in Multiple Myeloma, Dec 9th. Novel MoA, additive to, complementing existing treatments.
PRESS RELEASE: https://www.cellcentric.com/press-release/cellcentic-presents-latest-clinical-data-at-ash-promising-efficacy-and-safety-in-multiple-myeloma/ @DrEmmaSearle at #ASH24 shared latest positive inobrodib clinical data in treating multiple myeloma.
We will be sharing latest clinical data on Monday 5pm PT at #ASH24, San Diego. Inobrodib, our novel oral drug, new MoA, to treat multiple myeloma.
We will be at #ASH24, presenting latest Phase II data: New Drug in Multiple Myeloma, Dec 9th. Novel MoA, additive to, complementing existing treatments.
PRESS RELEASE: https://www.cellcentric.com/press-release/cellcentic-presents-latest-clinical-data-at-ash-promising-efficacy-and-safety-in-multiple-myeloma/ @DrEmmaSearle at #ASH24 shared latest positive inobrodib clinical data in treating multiple myeloma.
We will be sharing latest clinical data on Monday 5pm PT at #ASH24, San Diego. Inobrodib, our novel oral drug, new MoA, to treat multiple myeloma.
We will be at #ASH24, presenting latest Phase II data: New Drug in Multiple Myeloma, Dec 9th. Novel MoA, additive to, complementing existing treatments.
Latest press releases
Haematological cancers
Relapsed/refractory haematological cancers including Acute Myeloid Leukemia (AML), Multiple Myeloma (MM), Non-Hodgkin’s Lymphoma(NHL) and Myelodysplastic Syndromes (MDS)
Prostate
Cancer
Metastatic Castration Resistant Prostate Cancer (mCRPC). Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt
Targeted Tumours
inobrodib can potentially target tumours with amplified expression of certain tumour driving proteins that are regulated by p300/CBP.
Inobrodib was developed by CellCentric from initial hits through to an optimised compound and onto a clinical candidate. The compound has been evaluated extensively non-clinically, demonstrating its impact on p300/CBP inhibition in vivo.
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Inobrodib was developed by CellCentric from initial hits through to an optimised compound and onto a clinical candidate.
The compound has been evaluated extensively non-clinically, demonstrating its impact on p300/CBP inhibition in vivo.
View and download posters from recent key conferences
A Phase I/IIa study to evaluate the safety and efficacy of CCS1477, a first in clinic inhibitor of p300/CBP, as monotherapy in patients with selected molecular alterations
Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma
Inobrodib: A novel small molecule inhibitor of p300/CBP for the treatment of acute myeloid leukaemia and multiple myeloma
An open-label Phase I/IIa study to evaluate the safety and efficacy of Inobrodib, a first in clinic inhibitor of the p300/CBP bromodomains, as monotherapy in patients with advanced haematological malignancies
An open-label Phase I/IIa study to evaluate the safety and efficacy of Inobrodib as monotherapy and in combination in patients with advanced solid/metastatic tumours.
Inobrodib, a potent and selective p300/CBP bromodomain inhibitor, is targeted and differentiated from BET inhibitors in prostate cancer cell lines in vitro.
p300/CBP inhibitor CCS1477 targets 22Rv1 prostate tumour AR and c-Myc gene expression in vivo.
A first-in-class p300/CBP bromodomain inhibitor for the treatment of prostate cancer and hematologic malignancies.
Novel small molecule inhibitor of p300/CBP down-regulates androgen receptor (AR) and c-Myc for the treatment of prostate cancer and beyond
Therapeutic targeting of the p300/CBP bromodomain for the treatment of castration resistant prostate cancer (CRPC)
Targeting the bromodomain of p300/CBP for the treatment of castrate resistant prostate cancer