Tumours with specific molecular drivers

Paralogue lethality

Particularly in bladder and certain lung cancers, but also in Non-Hodgkin Lymphoma (NHL) tumours, there is a relatively high prevalence (up to 20%) of tumours with a loss of function mutation in either p300 or CBP.

There is pre-clinical evidence that the tumours are then dependent on the non-mutated paralogue, and thus sensitive to an inhibitor of both p300 and CBP.  

CCS1477 inhibits both p300 and CBP

Tumours with a mutation in one or other twin (paralogue) proteins, are likely to be more susceptible to Cellcentric's drug

Over-expression of MYC and AR

Additionally, given that CCS1477 is known to significantly impact androgen receptor (AR) and MYC expression, tumours that are driven by these factors are also being examined.  This represents specific populations in a wide range of tumour types, including breast cancers.