Study 01: Late stage prostate cancer
A Phase 1b/2a clinical trial is underway with Prof Johann de Bono, ICR/Royal Marsden Hospital, as Chief Investigator. Other sites are following in the UK including Belfast and Newcastle before expansion to the US including the Kimmel Cancer Center, TJU Philadelphia.
The initial phase is an incremental dose escalation exploring CCS1477 on its own, testing tolerability, biological effects and optimal dosing schedules. This will be followed by expansion into defined cohorts of patients, with CCS1477 being admistered on its own or in combination with one of either Xtandi (enzalutamide) or Zytiga (abiraterone).
If CCS1477 successfully progresses through clinical trials, over 80,000 patients annually, who are or become resistant to, second generation anti-hormonal drugs, could potentially benefit from being treated with CellCentric’s novel drug.
In addition, within clinical study 01, there is the ability to test CCS1477 in the dose expansion phase in patients with tumours with specific p300 or CBP gene mutations (bladder, lung cancer).