CCS1477; new collaborations announced exploring p300/CBP inhibition for prostate cancer treatment

​CellCentric and The Institute of Cancer Research, London, have signed a research agreement to further explore the effects of CellCentric’s drug candidate CCS1477 on prostate cancer. In addition, Karen Knudsen, Johann de Bono and Myles Brown have been granted a Prostate Cancer Foundation challenge award of $1m to investigate the molecular and biological effects of CCS1477 in the context of clinical impact.

CellCentric’s p300/CBP bromodomain inhibitor is clearly differentiated from BET inhibitors

CellCentric today presents its latest pre-clinical efficacy data on drug Candidate CCS1477, at the AACR’s Annual Prostate Cancer meeting, Orlando. This novel inhibitor which targets the bromodomain of p300/CBP, is advancing to the clinic early 2018. Latest results continue to support CCS1477’s anti-cancer efficacy, as well as its clear differentiation versus other epigenetic-related inhibitors targeting bromodomains (BET inhibitors), such as JQ-1, iBET-151 and OTX-015.

CellCentric presents at the Prostate Cancer Foundation annual retreat, Washington DC

CellCentric presents new data on drug Candidate CCS1477 and its relevance to the aggressive, castrate-resistant form of prostate cancer, at the 24th Annual Prostate Cancer Foundation Scientific Retreat. The PCF meeting is the foremost scientific conference on the biology and treatment of prostate cancer. This is a closed, invitation only event which brings together the best researchers, physicians and medical oncologists from academia, non-profit organisations and industry.

CellCentric exploring CCS1477 and p300/CBP inhibition for haematological cancers

Women Scientists Looking Through Microscope

CellCentric has signed an agreement with Laura Pasqualucci, Professor of Pathology and Cell Biology at Columbia University Medical School, New York USA, to explore the relevance of the company’s drug Candidate, CCS1477, in treating certain haematological cancers. This is in addition to existing collaborations with Professor Tim Somervaille, Consultant Haematologist and Senior Group Leader at the Cancer Research UK Manchester Institute and Professor Brian Huntly, Consultant Haematologist and Professor of Leukaemia Stem Cell Biology at the Cambridge Stem Cell Institute.

CellCentric at ASCO: further CCS1477 pre-clinical data. Johann de Bono to lead clinical evaluation

CellCentric’s oral drug candidate CCS1477 targets p300/CBP for the treatment of castrate resistant prostate cancer (CRPC), the lethal form of the disease. Further biomarker and efficacy data is presented today supporting its application both as a monotherapy and in combination with other drugs such as Enzalutamide. CellCentric is taking CCS1477 into the clinic in the UK and US, with Johann de Bono as the lead clinical Principal Investigator, a renowned world leader in the development of novel treatments for prostate cancer.

CellCentric presents further CCS1477 pre-clinical efficacy data at AACR

CellCentric’s cancer drug candidate CCS1477 is initially targeted for the treatment of castrate resistant prostate cancer (CRPC). Further supporting data is presented today at the 2017 annual meeting of the American Association for Cancer Research (AACR) in Washington, DC. CCS1477 can also be used against tumours that harbour p300 or CBP mutations, opening up application areas including bladder, lung and haematological cancers.

CellCentric’s novel p300/CBP inhibitor, CCS1477 advancing to the clinic

CellCentric has developed a potent, selective, orally bioavailable small molecule inhibitor of p300/CBP. These targets are key regulators of cancer cells, and specifically play a critical role in the progression of the aggressive form of prostate cancer. Key pre-clinical efficacy data on CellCentric’s compound CCS1477 is presented today at GU-ASCO, Orlando (1).

CellCentric wins Innovate UK award to expand use of p300/CBP inhibitors in cancer

CellCentric is developing first in class drug compounds against a key regulator of cancer. P300/CBP are twin (paralogue) histone acetyltransferase proteins, that act as transcriptional co-factors. When inhibited they cause the down regulation of the androgen receptor (AR) and its variants. It also decreases c-Myc, another key cancer driver.

CellCentric expands team to push forward to IND

CellCentric is developing proprietary anti-cancer compounds that target androgen receptor (AR) regulation. These hold promise for castrate resistant prostate cancer (CRPC) as well as other cancers. As the company moves towards Candidate selection and IND qualification, CellCentric is expanding its team for future activities.

CellCentric secures funding to take its prostate cancer programme to IND

Further investment from Morningside Venture Investments Ltd and Providence Investment Company Ltd will see the company take its small molecule drug discovery programme for the most aggressive form of prostate cancer (CRPC) through candidate finalisation and IND-enabling studies. CellCentric’s proprietary compounds target a histone acetyl transferase (HAT) that is key in androgen receptor regulation.