CellCentric raises $26 million to take first-in- class p300/CBP inhibitor into the clinic

CellCentric has raised $26 million in private financing to fund clinical testing of its first-in-class oncology drug candidate CCS1477. The funds will be used to test the novel p300/CBP inhibitor in late stage, treatment-resistant prostate cancer (up to Phase IIb). Recent data shared at AACR also highlighted the potential of CCS1477 in a range of […]

CellCentric at AACR 2018: first-in-class p300/CBP inhibitor drug candidate, for prostate cancer and beyond

Women Scientists Looking Through Microscope

CellCentric’s oral drug candidate CCS1477 addresses the large and growing population of late stage prostate cancer patients who have inherent or acquired resistance to current second-line anti-androgen therapies. It can be used after or in combination with abiraterone (Zytiga), enzalutamide (Xtandi) and apalutamide (Erleada). New pre-clinical data is presented today at the annual American Association of Cancer Research (AACR) meeting, Chicago, supporting its targeted use not just for prostate cancer (CRPC), but also for other indications including certain haematological cancers (AML and multiple myeloma).

AACR poster 2018: http://www.cellcentric.com/aacr-poster-2018.

CellCentric’s first-in-class p300/CBP inhibitor drug CCS1477; capsule production complete ready for the clinic

Production of CCS1477 in capsule form is now complete, ahead of forthcoming first-in-human clinical trials to investigate the novel drug’s tolerability and efficacy in treating late stage prostate cancer (CRPC). The active component is a p300/CBP bromodomain inhibitor that has a profound effect on the drivers of CPRC. It addresses the resistance seen in tumours treated with current second generation anti-hormonal drugs. Formulation and GMP manufacture of the capsules was carried out by Quay Pharma.

CCS1477; new collaborations announced exploring p300/CBP inhibition for prostate cancer treatment

​CellCentric and The Institute of Cancer Research, London, have signed a research agreement to further explore the effects of CellCentric’s drug candidate CCS1477 on prostate cancer. In addition, Karen Knudsen, Johann de Bono and Myles Brown have been granted a Prostate Cancer Foundation challenge award of $1m to investigate the molecular and biological effects of CCS1477 in the context of clinical impact.

CellCentric’s p300/CBP bromodomain inhibitor is clearly differentiated from BET inhibitors

CellCentric today presents its latest pre-clinical efficacy data on drug Candidate CCS1477, at the AACR’s Annual Prostate Cancer meeting, Orlando. This novel inhibitor which targets the bromodomain of p300/CBP, is advancing to the clinic early 2018. Latest results continue to support CCS1477’s anti-cancer efficacy, as well as its clear differentiation versus other epigenetic-related inhibitors targeting bromodomains (BET inhibitors), such as JQ-1, iBET-151 and OTX-015.

CellCentric presents at the Prostate Cancer Foundation annual retreat, Washington DC

CellCentric presents new data on drug Candidate CCS1477 and its relevance to the aggressive, castrate-resistant form of prostate cancer, at the 24th Annual Prostate Cancer Foundation Scientific Retreat. The PCF meeting is the foremost scientific conference on the biology and treatment of prostate cancer. This is a closed, invitation only event which brings together the best researchers, physicians and medical oncologists from academia, non-profit organisations and industry.

CellCentric exploring CCS1477 and p300/CBP inhibition for haematological cancers

Women Scientists Looking Through Microscope

CellCentric has signed an agreement with Laura Pasqualucci, Professor of Pathology and Cell Biology at Columbia University Medical School, New York USA, to explore the relevance of the company’s drug Candidate, CCS1477, in treating certain haematological cancers. This is in addition to existing collaborations with Professor Tim Somervaille, Consultant Haematologist and Senior Group Leader at the Cancer Research UK Manchester Institute and Professor Brian Huntly, Consultant Haematologist and Professor of Leukaemia Stem Cell Biology at the Cambridge Stem Cell Institute.

CellCentric at ASCO: further CCS1477 pre-clinical data. Johann de Bono to lead clinical evaluation

CellCentric’s oral drug candidate CCS1477 targets p300/CBP for the treatment of castrate resistant prostate cancer (CRPC), the lethal form of the disease. Further biomarker and efficacy data is presented today supporting its application both as a monotherapy and in combination with other drugs such as Enzalutamide. CellCentric is taking CCS1477 into the clinic in the UK and US, with Johann de Bono as the lead clinical Principal Investigator, a renowned world leader in the development of novel treatments for prostate cancer.

CellCentric presents further CCS1477 pre-clinical efficacy data at AACR

CellCentric’s cancer drug candidate CCS1477 is initially targeted for the treatment of castrate resistant prostate cancer (CRPC). Further supporting data is presented today at the 2017 annual meeting of the American Association for Cancer Research (AACR) in Washington, DC. CCS1477 can also be used against tumours that harbour p300 or CBP mutations, opening up application areas including bladder, lung and haematological cancers.