Inobrodib (CCS1477), first in class p300/CBP bromodomain inhibitor treating relapsed refractory multiple myeloma Cambridge, UK, December 11th, 2022 – CellCentric, a privately owned, clinical stage biotechnology company pioneering small molecule inhibition of p300/CBP to treat cancer, today announces clinical data for the first time at the 64th American Society of Haematology (ASH) Annual Meeting, New […]
CellCentric to present inobrodib Phase I multiple myeloma efficacy and safety data at the American Society of Haematology.
Kris Frese, formerly Co-Lead at the Cancer Biomarker Centre Preclinical Pharmacology Team at Cancer Research UK, joins as Director of Cancer Biology
Andrew Hughes, Chief Development Adviser, who has led over 50 oncology R&D programmes at AstraZeneca, joins the Board
Inobrodib is the first drug to target p300/CBP, a new way to treat specific cancers. Following a successful Phase I campaign, new funding will be used to progress clinical development towards to pivotal registration trials.
P300/CBP is an emerging target offering a new path to treat specific cancers. CCS1477, developed by CellCentric, is a small molecule inhibitor of the twin regulator proteins, and formulated as an oral capsule. CCS1477, a first-in-class compound is in parallel strands of clinical trials to treat endocrine resistant prostate cancer, haematological malignancies and targeted tumours (with particular mutations or molecular drivers). These are all significant clinical unmet needs. Following Phase 1b dose escalation and schedule setting conducted at 16 centres in the UK, CellCentric’s clinical programme is expanding into the US, with the FDA opening an IND for CCS1477 for solid tumours.
CellCentric has developed the first p300/CBP inhibitor of its kind, to treat targeted types of cancer. Today’s cornerstone Cancer Discovery publication summarises CCS1477 and its translational data, mapping the drug’s mechanism of action through to specific biological effects seen in late-stage prostate cancer patients. CCS1477 represents a new way to tackle large and clear clinical unmet needs; for prostate cancer patients whose tumour has progressed despite existing therapeutic options, including enzalutamide or abiraterone; for patients with haematological malignancies, including acute myeloid leukaemia, multiple myeloma and non-Hodgkin’s lymphoma; and for other molecularly targeted tumours.
CellCentric raises $33m to broaden clinical trials of its first-in-class p300/CBP inhibitor, CCS1477
CCS1477 is a novel drug in Phase I/II clinical trials to treat late stage prostate cancer, haematological malignancies as well as tumours with specific drivers (AR, MYC, or p300/CBP mutations). Based on the early data to date, CellCentric has gained further funding from Morningside Venture Investments to expand its clinical evaluation programme. Over 10 hospital sites are active in the UK, with clinical operations coming on board into the US, and then Europe early 2021.
CellCentric has developed CCS1477, the first p300/CBP inhibitor of its kind, for use in the treatment of multiple cancer types. The drug will transition into Phase II dose expansion clinical trials this summer. Expanding on UK-based clinical activities, the company is set to open US clinical sites for patient recruitment this summer.
ellCentric has signed an agreement with the Prostate Cancer Clinical Trial Consortium, LLC (PCCTC), headquartered in New York, to help select and manage US sites for the ongoing evaluation of CCS1477. Overall management of the clinical programme will be retained by CellCentric’s clinical team based at Alderley Park, Manchester.
CCS1477 is the first drug to be used in patients that specifically targets p300/CBP, offering a new route to treat specific drug-resistant cancers. A clinical trial in late stage prostate cancer is already well underway across multiple clinical centres, under the leadership of Johann de Bono of the Royal Marsden Hospital, Institute of Cancer Research, London. Dosing in patients with haematological malignancies has now begun in a new study, starting at the Christie Hospital, Manchester.
CellCentric’s first-in-class small molecule p300/CBP inhibitor, CCS1477, has been selected for the ‘New Drugs on the Horizon’ session at the prestigious annual American Association for Cancer Research (AACR) meeting, this year being held in Atlanta. CellCentric’sResearch Director, Neil Pegg, will be presenting on March 31st 2019. Neil’s presentation will include the first disclosure of the chemical structure of the molecule. The compound is now in Phase I patient clinical testing, initially for prostate cancer, moving on to haematological malignancies.